Methylation been discovered on a variety of lysine residues in varied histones: K4 (using the single-letter amino-acid code for lawyers in my area lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 within the globular domain of histone H4 2 and K26 of histone H1B 3 Several proteins liable for the methylation of particular residues have been characterised, and all however one among these comprises a SET domain